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Pharma downstream solutions

Cut complexity and risk across your pharma downstream processing – from sterile filtration and crystal dewatering to gentle final drying. Our advanced mechanical  and thermal separation technologies help pharmaceutical producers overcome today’s toughest challenges with hygienic design, full batch traceability, and GMP-compliant performance.

Let us tackle the challenges in the pharmaceutical industry together

Purity and Regulatory Compliance

Prevent contamination and ensure GMP compliance

Eliminate dead zones, avoid lubricant ingress, and maintain fully enclosed, cleanable process areas

Complete batch traceability with audit-ready records, logging every operator action and parameter change

Product Integrity and Operational Efficiency

Gentle handling of APIs and rapid changeovers

Preserve yield and potency for shear- and heat-sensitive actives.

Validated CIP/SIP procedures minimize downtime in multiproduct facilities.

Scalability and Sustainability

Boost capacity responsibly and maintain global standards

Increase production while reducing energy consumption and accelerating drying cycles.

Achieve higher permeate flux without compromising quality as demand grows.

Key benefits at a glance, when working with ANDRITZ

  • Regulatory confidence: Hygienic design, verified CIP/SIP, and batch‑logging software functions.
  • Product quality & yield: Single‑pass, low‑stress filtration; excellent wash efficiency; gentle, uniform drying.
  • Operational efficiency: Higher permeate flux, up to 80% lower filtration energy, fast product changeovers, and scalable portfolio from lab to full scale.

Insulin production: purity and performance in every step

Insulin manufacturing demands absolute precision and uncompromising quality—and that’s where our solutions shine. From the first harvest to the final drying stage, we deliver a fully integrated approach that safeguards product integrity while boosting efficiency.

Insulin manufacturing demands absolute precision and uncompromising quality—and that’s where our solutions shine. From the first harvest to the final drying stage, we deliver a fully integrated approach that safeguards product integrity while boosting efficiency.

  • Harvest & concentration: Dynamic Cross-Flow Filter (DCF) ensures gentle, single-pass filtration with GMP-ready batch logging, protecting sensitive molecules and streamlining compliance.
  • Crystallization & dewatering: PUREVO pharma peeler centrifuges and vertical peeler centrifuges provide crystal washing and dewatering with hygienic design and repeatable discharge for maximum purity.
  • Final drying: Helix dryers complete the process with uniform, low-shear vacuum drying that guarantees consistent results and fast, validated changeovers.

The result? A downstream line that meets the toughest regulatory standards while driving yield, speed, and confidence—batch after batch. 

Dynamic crossflow filters have modernized insulin production

Process know-how and innovation

Transforming lives through innovation: Novo Nordisk partnered with ANDRITZ to ensure consistent purity and optimized yield for vital diabetes treatments.

Equipment for pharma downstream processing

Dewatering, filtration and screening

DCF for pharmaceutical industry

Dynamic Cross-Flow Filter (DCF)

- Cell harvest 

- Protein concentration/diafiltration

- Polishing steps in biologics such as insulin

PUREVO pharma peeler centrifuge

- APIs and intermediates 

- Antibiotics, vitamins, 

- Other fine chemical products requiring high wash quality and containment

Vertical centrifuge with large opening area for inspection

Vertical peeler centrifuge

- Pharmaceuticals, including crystal washing and dewatering of API intermediates

- Fine chemicals, agrochemicals

se-products-drying systems-helix dryer hd_pic1

Helix dryers (vacuum contact drying)

- Active pharmaceutical ingredients (APIs)

- Antibiotics, amino acids, and pharmaceutical intermediates

- Fine chemicals

 

Medicine

Screening components

- Superior product quality

- Preservation of active ingredients

- Flexibility and versatility

Solidification and drying

Dedert_spray_dryer_key-visual

Spray dryer

- Oil-free and contact-free

- Simple and ultra-sanitary

- Sustainable and energy-efficient

- Reliable and low-maintenance

Air Bearing Atomizer

Air bearing atomizer

- Oil-free and contact-free

- Reliable and low-maintenance

- Simple and sanitary

- Sustainable and energy-efficient

se-products-thermal-systems-drum-flaker-pic1

Drum flaker

- Maximum Efficiency

- Coolant circulation provides optimum heat transfer

- Dust or gas tight model

ANDRITZ plate dryer

Plate dryer

- High product quality

- Operational flexibility and ease of use

- Energy efficiency and clean operation

ANDRITZ fluid bed dryer

Fluid bed dryer

- Gentle yet efficient processing

- Operational flexibility and simplicity

- Low maintenance requirements

Automation, digitalization, and lifecycle support

Metris addIQ control systems with touch screen panel

Advanced control and digital twins

ANDRITZ addIQ control systems and DCF digital twin capabilities help operators

-  Hit optimal setpoints, 

- Simulate “what‑if” scenarios, 

- Continuously improve performance.

 

Service

Global service and validation support

From installation and commissioning to preventive maintenance, audits, and training.

Our global service network supports the full equipment lifecycle in regulated environments.

Ready to engineer your downstream line?

Whether you’re optimizing an existing insulin line or designing a new multiproduct facility, our process experts can help size, test, and integrate our solutions for your specific targets in purity, throughput, and cost efficiency. Contact us today and see how ANDRITZ can help you boost your productivity and increase efficiency.

 

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Solutions you can count on in the chemicals industry
Solutions you can count on in the chemicals industry
PDF: 3.1 MB
Krauss-Maffei dynamic crossflow filter DCF
Krauss-Maffei dynamic crossflow filter DCF
PDF: 1.2 MB
PUREVO pharma peeler centrifuge
PUREVO pharma peeler centrifuge
PDF: 1.5 MB
ANDRITZ helix dryer
ANDRITZ helix dryer
PDF: 1.5 MB
A world of service

Your full-service provider

A world of service

Your full-service provider

PDF: 1.5 MB
Metris addIQ control systems

Intelligence for machine and process control

Metris addIQ control systems

Intelligence for machine and process control

PDF: 637 KB